Search
The Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM) enables structural analysis of challenging proteins and macromolecules with exceptional ease of use, making cryo-EM accessible to both new and experienced users at a price point aligned with typical funding sources. Designed to accelerate workflows, it supports rapid sample loading, iterative optimization, and streamlined data collection with minimal training, helping researchers move quickly from sample screening to high-quality results. The Tundra Cryo-TEM empowers laboratories to generate meaningful structural insights in-house and confidently advance discovery.
Tundra Cryo-TEM benefits
100 kV for high-resolution cryo-EM
The optics of the Tundra Cryo-TEM are specifically designed to generate high-contrast biological images routinely at near-atomic resolution with medium throughput.
Featured on the cover of Structure, this study demonstrates that the Tundra Cryo-TEM paired with the Thermo Scientific Falcon C Direct Electron Detector achieves sub-3 Å resolution across a diverse set of biological macromolecules. This pushes the boundaries of what’s possible with lower-voltage, more accessible cryo-EM systems, enabling high-resolution structures.
Rabbit muscle aldolase imaged to 2.8 Å as reported in D. Karia et al.
Shorten time to cryo-EM sample selection
The Tundra Cryo-TEM can visualize the impact of biochemical adjustments to samples faster than other technologies. Exchange samples in and out of the microscope in minutes, with nearly instantaneous feedback, allowing you to optimize your sample conditions quickly without extensive training.
An example of cryo-EM sample behaving differently in ice. Sample courtesy of Guillaume Lebon, Université Montpellier, CNRS, INSERM.
Designed to meet your budget
A wide range of funding proposals and grants were considered when designing the Tundra Cryo-TEM to keep its price within the reach of most instrumentation grants. Our Electron Microscopy Funding Support Center has additional information about our financial services as well as grant-writing guidance so you can get the tools you need, when you need them.
Advanced cryo-TEM software takes the guesswork out of cryo-TEM
The Tundra Cryo-TEM comes with a complete suite of automation software for efficient optimization of your sample’s biochemistry as well as data collection for structural determination. This includes a user-friendly AI-enabled software solution capable of analyzing intermediate results, providing instant feedback, and steering data collection on the fly. Our AI algorithms are based on years of cryo-EM knowledge, providing expert decisions upfront to ensure that your instrument is working at optimal conditions. This allows you to focus on the science rather than on fine-tuning the microscope.
Tundra Cryo-TEM features
The Tundra Cryo-TEM is equipped with a 100 kV high-brightness field emission gun (X-FEG) that allows for high resolution structure determination at routinely 3-5 Å. The Tundra Cryo-TEM can be installed with either the Falcon C Direct Electron Detector or Thermo Scientific Ceta F CMOS Detector. The Falcon C Direct Electron Detector provides a boost in contrast for single particle cryo-EM, improving resolution and obtaining results faster with less data to maximize your resolution efforts. Tundra Cryo-TEM with the Falcon C Direct Electron Detector makes it possible to efficiently solve protein structures 100 kDa or less.
Tundra Cryo-TEM loading station
An integrated loader makes it easier for users of any experience level to load samples into the microscope, as compared to conventional systems. Scientists can exchange sample carriers in minutes. Results can be checked immediately, allowing users to rapidly optimize biochemistry sample conditions.
The cryo-loading station stays cold for approximately 6.5 hours. With a 20-minute loading and unloading cycle, as well as time for sample quality analysis, users can exchange up to 10 sample grids a day.
Tundra Cryo-TEM technical specifications
Source |
|
Accelerating voltage |
|
Semi-automated sample loading |
|
Lenses |
|
Stage |
|
Imaging options |
|
Room size requirements (L x W X H) |
|
Software |
|
Tundra Cryo-TEM floor-plan and installation requirements
- Environmental temperature: 18–23°C
- Temperature stability: 1°C per 24 hours
- Relative humidity: <60%
- All-in-one room dimensions: 4.20 x 4.00 m (13.8 x 13.1 ft)
- Dimensions with cryo-loading station in neighboring room: 4.00 x 3.80 m (13.1 x 12.5 ft)
- Ceiling height: 2.74 m (8.99 ft)
- Door height: 2.30 m (7.55 ft); can be optionally reduced to 1.97 m (6.5 ft)
- Door width: 1.00 m (3.28 ft)
- Weight distribution maximum: 700 kg/m2
- Double earth connection
- Frequency: 50 or 60 Hz (±3%)
- Compressed air supply with a pressure range of 5–7 bar
- Sulfur hexafluoride (SF6) gas in properly ventilated room
- LAN connection for Thermo Scientific RAPID Service (Remote Access Program for Interactive Diagnosis)
For Research Use Only. Not for use in diagnostic procedures.