We've got a column for that!
Solve your separation challenge with your new favorite column. Bringing you Thermo Scientific Accucore, Acclaim, and Hypersil GOLD premier HPLC and UHPLC columns, which feature:
- High resolution, high pressure UHPLC and HPLC columns
- A 40-year legacy of innovation
- Unmatched variety of chemistries, particle sizes, and column formats
- From the most popular C18 phases, to innovative mixed mode chemistries, we have the right column for your separation needs
- Long lifetime and reproducible
- The broadest range of solid core columns on the market
Accucore
Solid core for high resolution
- Fast separation on limited sample volume
- Increased sensitivity using standard HPLC
- High resolution without elevated backpressure
Acclaim
Fully porous for complicated samples
- Complex mixtures
- Higher resolution
- More phases, more choices
Hypersil GOLD
Fully porous for simple samples
- Great starter columns
- Fast method development
- Great for general analyses
Webinar
Understanding Diversity in HPLC Chromatography Chemistries
Learn how to choose your HPLC chemistry
- What’s the best column to maximize your productivity?
- Understanding the wide spectrum of selectivities
- Superficially porous vs. fully porous packing material
- Unique phases for challenging sample mixtures
Take a closer look
Accucore HPLC & UHPLC Columns
Discover more
- High resolution separation on rugged solid core (superficially porous) particles
- Fast and easy analyses with a wide selection of chemistries
- Increased sensitivity on a standard HPLC system
- Compatible with almost any instrument
- An excellent return on investment
15 Accucore chemistries to choose from
Accucore phase overview
Accucore Vanquish UHPLC columns
Using 1.5 μm solid core particles, allow UHPLC users to enjoy performance benefits over columns packed with conventional sub-2 μm fully porous particles
| Phase name | Particle type (μm) | Carbon load (%) | USP |
|---|---|---|---|
| C18+ | 1.5 | 6.5 | L1 |
Accucore HPLC columns for biomolecules
The range of Accucore HPLC columns packed with 150 Å pore diameter particles allows biomolecule separations to benefit from the superb resolution and high speed enabled by solid core technology.
| Phase name | Particle type (μm) | Carbon load (%) | USP |
|---|---|---|---|
| 150-C18 | 2.6 | 7 | L1 |
| 150-C4 | 2.6 | 2 | L26 |
| 150-Amide-HILIC | 2.6 | – | – |
Accucore XL HPLC columns
Using 4 μm solid core particles, Accucore XL HPLC columns allow users of conventional HPLC methods to enjoy performance far beyond that of columns packed with 5 μm, 4 μm or even 3 μm fully porous particles.
Accucore HPLC columns
Containing solid core particles having a 2.6 μm diameter and a very narrow particle size distribution high speed, high resolution separations
| Phase name | Particle type (μm) | Carbon load (%) | USP |
|---|---|---|---|
| RP-MS | 2.6 | 7 | L1 |
| C18 | 2.6 | 9 | L1 |
| C8 | 2.6 | 9 | L7 |
| aQ | 2.6 | 9 | L1 |
| Polar Premium | 2.6 | 8 | L60 |
| Biphenyl | 2.6 | 6 | L11 |
| Phenyl-Hexyl | 2.6 | 5 | L11 |
| PFP | 2.6 | 5 | L43 |
| Phenyl-X | 2.6 | 6 | – |
| C30 | 2.6 | 5 | L62 |
| HILIC | 2.6 | – | L3 |
| Urea-HILIC | 2.6 | – | – |
Learn more about Accucore columns
Popular Accucore column application notes
Acclaim HPLC & UHPLC Columns
Resolve more
- The go-to column for complex mixtures that require more resolution
- More phases, more choices
- Fully porous with a high surface area, ensuring high retention
- Designed for complicated samples
- Separates and resolves compounds not possible with other columns
21 Acclaim chemistries to choose from
General-purpose RP
Separate complex samples with high surface area columns (C18, etc).
Mixed-mode
Retain multiple types of analytes on a single column.
Application-specific
Unique columns for specific applications: surfactants, organic acids, pesticides, aminoglycosides, explosive residues.
HILIC
Designed for the separation of polar compounds.
Acclaim phase overview
| Phase Name | 2.2 µm | 3.0 µm | 5.0 µm | Pore Diameter (Å) | Surface Area(m²/g) | Carbon Load (%) | USP |
|---|---|---|---|---|---|---|---|
| Acclaim 120 C18 |  | | | 120 | 300 | 18 | L1 |
| Acclaim 120 C18 Vanquish | | — | — | 120 | 300 | 18 | L1 |
| Acclaim 120 C8 | | | | 120 | 300 | 11 | L7 |
| Acclaim 300 C18 | — | | — | 300 | 100 | 8 | L1 |
| Acclaim Polar Advantage | | | | 120 | 300 | 17 | L60 |
| Acclaim Polar Advantage 2 | | | | 120 | 300 | 17 | L60 |
| Acclaim PA2 Vanquish | | — | — | 120 | 300 | 17 | L60 |
| Acclaim C30 | — | | | 200 | 200 | 13 | L62 |
| Acclaim Phenyl-1 | — | | | 120 | 300 | 13 | L11 |
| Acclaim HILIC-10 | — | | — | 120 | — | 8 | — |
| Acclaim Organic Acid | — | | | 120 | 300 | 17 | — |
| Acclaim Surfactant | — | | | 120 | 300 | 12 | — |
| Acclaim Surfactant Plus (for LC-MS / CAD) | — | | | 120 | 300 | — | — |
| Acclaim Explosives E2 | | | | 120 | 300 | — | — |
| Acclaim Carbamate | | | | 120 | 300 | — | — |
| Acclaim Carbonyl | | | | 120 | 300 | — | — |
| Acclaim Trinity Q1 | — | | — | 300 | 100 | — | — |
| Acclaim AmG C18 | — | | — | 120 | 300 | — | — |
| Acclaim Trinity P1 | — | | — | 300 | 100 | — | — |
| Acclaim Trinity P2 | — | | — | 300 | 100 | — | — |
| Acclaim Mixed-Mode WAX-1 | — | | | 120 | 300 | — | L85 |
| Acclaim Mixed-Mode HILIC-1 | — | | | 120 | 300 | — | — |
| Acclaim Mixed-Mode WCX-1 | — | | | 120 | 300 | — | L78 |
| Acclaim SEC-1000 | — | — | 7µm | 1,000 | — | — | L38 |
| Acclaim SEC-300 | — | — | 5µm | 300 | — | — | L25 |
Learn more about Acclaim columns
Popular Acclaim column application notes
Hypersil GOLD HPLC & UHPLC Columns
Back to basics
- The go-to, easy-to-use HPLC columns for many chromatographic separations
- Built on 40 years of experience in column development and manufacturing
- Outstanding peak shape for reversed phase, ion exchange, HILIC, or normal phase chromatography
- Excellent resolution, efficiency and sensitivity
Complete range of Hypersil GOLD columns to start your chromatographic separation
| Hypersil GOLD Hypersil GOLD C8 Hypersil GOLD C4 |  | Traditional reversed-phase columns for hydrophobic interaction; C8 and C4 are better when less hydrophobicity is needed. |
| Hypersil GOLD aQ | | Good for basic compound separations by reversed-phase using aqueous mobile phase. |
| Hypersil Phenyl Hypersil PFP | | Aromatic compounds are separated better with these columns. |
| Hypersil AX Hypersil SAX Hypersil Amino | | Ion exchange columns are preferred for ionic compounds. |
| Hypersil HILIC Hypersil Silica | | Polar compounds are retained and separated well with these hydrophilic columns. |
Hypersil GOLD phase overview
| Phase Name | 1.9 µm | 3.0 µm | 5.0 µm | 12.0 µm | Carbon Load (%) | USP | pH Range |
|---|---|---|---|---|---|---|---|
| Hypersil GOLD C18 | | | | | 10 | L1 | 2 to 11 |
| Hypersil GOLD C8 | | | | — | 8 | L7 | 2 to 9 |
| Hypersil GOLD C4 | | | | — | 5 | L26 | 2 to 8 |
| Hypersil GOLD aQ | | | | — | 12 | L1 | 2 to 9 |
| Hypersil GOLD PFP | | | | — | 8 | L43 | 2 to 8 |
| Hypersil GOLD Phenyl | | | | — | 8 | L11 | 2 to 8 |
| Hypersil GOLD CN | | | | — | 4 | L10 | 2 to 8 |
| Hypersil GOLD Amino | | | | — | 2 | L9 | 2 to 8 |
| Hypersil GOLD AX | | | | — | 6 | — | 2 to 8 |
| Hypersil GOLD SAX | | | | — | 2.5 | L14 | 2 to 8 |
| Hypersil GOLD Silica | | | | — | — | L3 | 2 to 8 |
| Hypersil GOLD HILIC | | | | — | 6 | — | 2 to 8 |
Learn more about Hypersil GOLD columns
Popular Hypersil GOLD column application notes
Know your options
A great resource to know and compare columns
- Overview column chemistries
- Column comparison chart
- Solid core versus fully porous supports
- Pore size versus surface area
- Quick guide to choosing a phase
- Plus, ordering information
