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Designed to maximize process efficiency
Advanced Granulation Technology (AGT) supports connected cell culture workflows by offering a simple approach to media preparation, contributing to process reliability from development through manufacturing.
Using advanced granulation techniques, the AGT format facilitates the production of complete formulations in serum-free, protein-free, and chemically defined media. Each lot is pH- and osmolality pre-adjusted for rapid dissolution, helping shorten preparation time compared with conventional dry-powder media (DPM). By adopting AGT, you can gain the productivity of a ready-to-hydrate medium with the storage and transport efficiency of a dry format, supporting consistency and performance across bioprocessing workflows.
Benefits of using AGT in your workflow
Incorporating AGT into your cell culture workflow helps simplify preparation and strengthen process consistency from development through commercial manufacturing.
Incorporating AGT into your workflow can help you:
- Increase efficiency with faster hydration and fewer manual steps
- Minimize storage and QC demands using a pre-adjusted dry format
- Maintain scalability with equivalent performance to liquid media
- Lower life cycle costs (LCC) through simplified planning and procurement
The following table compares the workflow considerations for conventional DPM and the advantages of AGT dry-media formats.
Advantages and considerations of DPM versus AGT dry-media formats
Workflow stage |
Considerations for dry-powder media |
Advantages of AGT |
Composition |
Requires sourcing and blending multiple raw materials before use |
Contains a single, complete formulation produced as dry granules through advanced granulation techniques |
Preparation |
Requires multi-step hydration and separate pH and osmolality adjustments |
Features pre-adjusted granules that dissolve quickly for uniform hydration |
Processing time |
Requires extended preparation and mixing steps that increase process time |
Designed for rapid dissolution, helping shorten preparation and setup time |
Storage and handling |
Requires large storage areas and multiple containers, increasing complexity |
Offers a compact dry format designed to simplify handling and reduce space requirements |
Quality control |
Requires individual quality control checks for each raw material |
Involves fewer components, which allows for reduced monitoring |
Scalability |
Requires optimization when processes are scaled to larger volumes |
Demonstrates consistent performance from development through commercial manufacturing |
Operational efficiency |
Requires time- and labor-intensive preparation steps that may slow production |
Supports a streamlined workflow that increases overall operational efficiency |
Ordering information
Supporting diverse applications and modalities
AGT media are used across bioprocessing modalities, supporting consistent growth and scalability from research to commercial production.
Explore other media for consistent cell growth
Explore cell culture media options to find the right format and composition for your bioprocessing workflow. Each is produced under cGMP conditions and backed by the same commitment to consistency, quality, and scalability.
Frequently asked questions
AGT is a granulated dry-medium format produced using advanced granulation techniques designed to simplify cell culture preparation and improve process consistency. Each AGT formulation contains complete, pre-adjusted nutrients in granular form that dissolve quickly in water for uniform hydration. Produced under cGMP conditions, AGT supports reliable growth across development and manufacturing workflows.
AGT media replace conventional dry powder media (DPM) blends with a single, complete granular medium, eliminating the need for multi-component weighing and mixing. The granules are pre-adjusted for pH and osmolality, designed to dissolve rapidly to help shorten preparation time and reduce variability. Incorporating AGT media into your workflow allows for lower storage and handling needs because the format requires fewer containers, and incoming QC is simplified. Hydration behavior is predictable across scales, supporting consistent performance.
AGT media make it easy to move from small-scale liquid processes to large-scale production. This format offers the same performance as liquid media with the added benefit of being simpler to store, ship, and mix - just add water. This facilitates faster, cleaner, and more efficient scaling without changing your process.
AGT media are designed for quick preparation. The granules are dissolved directly in water for injection or cell culture-grade water, eliminating the need for separate pH and osmolality adjustments. Once fully dissolved, the solution is sterile filtered to create ready-to-use liquid media. This process helps reduce preparation time and handling steps while maintaining outcomes across batches and scales.
AGT media are manufactured under cGMP conditions and meet rigorous quality control standards for traceability, documentation, and reproducibility. Each lot is thoroughly tested to confirm its physical, chemical, and functional consistency, making it suitable for use in regulated bioprocessing environments. The dry format simplifies inventory management and preparation within cGMP-compliant facilities.
Gibco Cell Culture Media
Additional bioprocessing resources
Bioprocessing resources
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.