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Induced Pluripotent Stem Cells (iPSCs)
Since the discovery that human and mouse fibroblasts could be reprogrammed to generate induced pluripotent stem cells (iPSCs) with qualities similar to embryonic stem cells, iPSCs have proven to be a valuable tool in basic research, drug discovery, and cell therapy. iPSCs enable the generation of patient-specific cell models while avoiding the ethical considerations associated with embryonic stem cells. Because they retain the donor’s genetic background, iPSCs are powerful tools for disease modeling, drug screening, toxicology studies, and precision medicine research.
iPSC reprogramming methods typically deliver key transcription factors to convert somatic cells into a pluripotent state. Common approaches include integration-free technologies such as Sendai virus–based systems and episomal plasmid methods. iPSCs are commonly maintained in defined, feeder-free culture systems using optimized pluripotent stem cell media and recombinant extracellular matrices. Routine passaging, either enzymatic or non-enzymatic, helps preserve colony morphology and pluripotency.
Our products have been an integral part of induced pluripotent stem cell research from the initial discovery of iPSCs to current breakthroughs. Our comprehensive portfolio of stem cell research products provides optimized tools for each step of the stem cell workflow: from reprogramming somatic cells to iPSC expansion and differentiation.
Recommended product guide for induced pluripotent stem cell research
Explore iPSC workflow solutions:
- Reprogramming technologies: Integration-free systems designed for efficient somatic cell reprogramming.
- Pluripotent stem cell culture media: Defined, feeder-free media optimized for consistent iPSC maintenance.
- Extracellular matrices: Recombinant substrates that support robust attachment and expansion.
- Passaging methods: Enzymatic and non-enzymatic options for routine subculture.
- Characterization assays: Gene expression and marker-based tools to confirm pluripotency and differentiation potential.
Recommended product guide for induced pluripotent stem cell research
Reprogramming of somatic cells for iPSC generation can be accomplished with a number of technologies. We offer choices in integration-free reprogramming technologies that fit your research and translational needs including our Cell Therapy Systems (CTS) Products, which are designed for clinical and translational research applications.
Reprogram human iPSCs
Reprogramming tools
Transfection tools
Cell identification
iPSC research requires careful attention to culture conditions. From feeder-based and feeder-free media to optimized passaging reagents and substrates to media for stem cell therapy research, Gibco products enable you to culture with confidence.
Culture human iPSCs
Media and reagents
Passaging reagents
Stem cell therapy media and reagents
Engineered PSCs can be utilized in a variety of applications, including disease modeling, differentiation and development studies, and regenerative medicine. Choose from Invitrogen gene editing and transfection technologies to build better cell models.
Engineer human iPSCs
Transfection tools
Gene editing tools
Media and reagents
Learn more
iPSC differentiation requires standardized culture methods to ensure reproducible and reliable results. Gibco media, supplements, substrates, growth factors and cytokines provide you with an easy-to-use, flexible set of tools for targeted differentiation of induced pluripotent stem cells. Our differentiation portfolio allows optimal growth, expansion and storage of differentiated cells—enabling faster, more efficient systems.
Differentiate human iPSCs
Differentiation kits
Media and supplements
Growth factors
Plasticware
Learn more
Analyze stem cells and their derivatives using a wide range of cellular and molecular tools, as characterization is critical in iPSC research. Whether analyzing proliferation, protein levels, gene expression, or epigenetic profiles, we have the right instruments and products for your research.
Characterize human iPSCs
Genomic analysis
Labeling and detection tools
Protein analysis
Sample preparation
Featured instruments:
Recommended products
Cellular characterization
Genomic characterization
Cell identity confirmation
Learn more
Reprogramming of somatic cells for iPSC generation can be accomplished with a number of technologies. We offer choices in integration-free reprogramming technologies that fit your research and translational needs including our Cell Therapy Systems (CTS) Products, which are designed for clinical and translational research applications.
Reprogram human iPSCs
Reprogramming tools
Transfection tools
Cell identification
iPSC research requires careful attention to culture conditions. From feeder-based and feeder-free media to optimized passaging reagents and substrates to media for stem cell therapy research, Gibco products enable you to culture with confidence.
Culture human iPSCs
Media and reagents
Passaging reagents
Stem cell therapy media and reagents
Engineered PSCs can be utilized in a variety of applications, including disease modeling, differentiation and development studies, and regenerative medicine. Choose from Invitrogen gene editing and transfection technologies to build better cell models.
Engineer human iPSCs
Transfection tools
Gene editing tools
Media and reagents
Learn more
iPSC differentiation requires standardized culture methods to ensure reproducible and reliable results. Gibco media, supplements, substrates, growth factors and cytokines provide you with an easy-to-use, flexible set of tools for targeted differentiation of induced pluripotent stem cells. Our differentiation portfolio allows optimal growth, expansion and storage of differentiated cells—enabling faster, more efficient systems.
Differentiate human iPSCs
Differentiation kits
Media and supplements
Growth factors
Plasticware
Learn more
Analyze stem cells and their derivatives using a wide range of cellular and molecular tools, as characterization is critical in iPSC research. Whether analyzing proliferation, protein levels, gene expression, or epigenetic profiles, we have the right instruments and products for your research.
Characterize human iPSCs
Genomic analysis
Labeling and detection tools
Protein analysis
Sample preparation
Featured instruments:
Recommended products
Cellular characterization
Genomic characterization
Cell identity confirmation
Learn more
Which stem cell reprogramming technology is right for you?
Explore integration-free reprogramming options, including Sendai virus and episomal technologies, to find the right balance of efficiency, workflow simplicity, and application fit for your research.
Choosing the right pluripotent stem cell culture medium
Compare defined, xeno-free, feeder-free, and flexible culture media designed to support consistent iPSC maintenance and expansion.
Key considerations for choosing the right extracellular matrix
Select from recombinant, defined matrices optimized for robust attachment, survival, and pluripotency in feeder-free culture systems.
Selecting the right passaging method
Evaluate enzymatic, non-enzymatic, and mechanical passaging options to match your culture conditions and downstream applications.
Which iPSC detection method is right for you?
Confirm pluripotency and differentiation potential with validated assays, live-cell stains, and gene expression tools.
Stem Cell Research Resource Library
Explore a wide selection of free tools and resources to support every step of your stem cell workflow through our Stem Cell Research Resource Library. This includes application notes, handbooks, protocols, scientific posters, trainings, videos, webinars, and more.
Looking for additional protocols?
Find detailed protocols for stem cell research, including pluripotent stem cell maintenance, feeder-dependent and feeder-free cultures, reprogramming, differentiation, and characterization.
Resources
Intended use of the products mentioned on this page vary. For specific intended use statements please refer to the product label.
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